Objective assessment of cortical activity changes in stroke patients before and after hand rehabilitation with and without botulinum toxin injection
Background Upper limb spasticity is a disabling condition and may result in severe functional limitation.The peripheral action of botulinum toxin (BTX) injection on spasticity is well known, but there are debates around its possible central action.Aim The aim of this study was to assess the clinical, functional, and cortical activation outcome of t